Enzyme-Linked Immunospot Assay Responses to Early Secretory Antigenic Target 6, Culture Filtrate Protein 10, and Purified Protein Derivative among Children with Tuberculosis: Implications for Diagnosis and Monitoring of Therapy | Zendy

Mark P. Nicol | Zendy; D. Pienaar | Zendy; Kathryn Wood | Zendy; Brian Eley | Zendy; Robert J. Wilkinson | Zendy; Heather Henderson | Zendy; Liezel Smith | Zendy; David Beatty | Zendy

Open Access

Enzyme-Linked Immunospot Assay Responses to Early Secretory Antigenic Target 6, Culture Filtrate Protein 10, and Purified Protein Derivative among Children with Tuberculosis: Implications for Diagnosis and Monitoring of Therapy

Author(s) -

Mark P. Nicol,

D. Pienaar,

Kathryn Wood,

Brian Eley,

Robert J. Wilkinson,

Heather Henderson,

Liezel Smith,

David Beatty

Publication year - 2005

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/429245

Subject(s) - medicine , tuberculosis , microbiology and biotechnology , enzyme , antigen , purified protein derivative , mycobacterium tuberculosis , virology , immunology , biochemistry , biology , pathology

The ability to detect tuberculosis-specific lymphocytes by enzyme-linked immunospot (ELISPOT) assay may have important implications for the diagnosis and monitoring of tuberculosis in children, for which routine methods lack sensitivity. We conducted a study to determine the presence and time course of ELISPOT responses in children with tuberculosis.

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