Production of Chemokines in the Lungs of Infants with Severe Respiratory Syncytial Virus Bronchiolitis | Zendy

Paul McNamara | Zendy; Brian Flanagan | Zendy; C. Anthony Hart | Zendy; Rosalind L. Smyth | Zendy

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Production of Chemokines in the Lungs of Infants with Severe Respiratory Syncytial Virus Bronchiolitis

Author(s) -

Paul McNamara,

Brian Flanagan,

C. Anthony Hart,

Rosalind L. Smyth

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/428855

Subject(s) - bronchiolitis , respiratory system , virus , medicine , virology , chemokine , immunology , biology , inflammation

Respiratory syncytial virus (RSV) bronchiolitis in infants is characterized by a massive neutrophilic infiltrate into the airways. Chemokines direct migration of leukocytes and contribute to the pathogenesis of RSV disease. However, little is known about pulmonary chemokine responses to RSV in humans. Our aim was to characterize the production of chemokines in the lungs of infants with RSV bronchiolitis and how this production changes over time.

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