Use of RNA Interference to Prevent Lethal Murine West Nile Virus Infection | Zendy

Fengwei Bai | Zendy; Tian Wang | Zendy; Utpal Pal | Zendy; Fukai Bao | Zendy; L. Hannah Gould | Zendy; Erol Fikrig | Zendy

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Use of RNA Interference to Prevent Lethal Murine West Nile Virus Infection

Author(s) -

Fengwei Bai,

Tian Wang,

Utpal Pal,

Fukai Bao,

L. Hannah Gould,

Erol Fikrig

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/428507

Subject(s) - west nile virus , virology , small interfering rna , virus , rna interference , biology , viral interference , flavivirus , viral replication , rna , in vivo , gene , genetics

West Nile virus causes fatal encephalitis in humans, mice, and other vertebrates. In the present study, we demonstrate that small interfering RNAs (siRNAs) inhibit West Nile virus replication in vitro. Moreover, the administration of siRNAs to mice by hydrodynamic injection 24 h before challenge with an intraperitoneal inoculum of West Nile virus reduced the viral load and afforded partial protection from lethal infection. These data show the efficacy of the prophylactic use of siRNAs against a viral infection in vivo and suggest new strategies to combat West Nile virus.

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