Cross‐Reactivity of Anti–HIV‐1 T Cell Immune Responses among the Major HIV‐1 Clades in HIV‐1–Positive Individuals from 4 Continents | Zendy

Paul Coplan | Zendy; Swati Gupta | Zendy; Sheri Dubey | Zendy; Punnee Pitisuttithum | Zendy; Alex Nikas | Zendy; Bernard Mbewe | Zendy; Eftyhia Vardas | Zendy; Mauro Schechter | Zendy; Esper G. Kallás | Zendy; Dan Freed | Zendy; TongMing Fu | Zendy; T. Christopher Mast | Zendy; Pilaipan Puthavathana | Zendy; James G. Kublin | Zendy; Kelly Collins | Zendy; John Chisi | Zendy; Richard Pendame | Zendy; Scott J. Thaler | Zendy; Glenda Gray | Zendy; James McIntyre | Zendy; Walter L. Straus | Zendy; Jon H. Condra | Zendy; Devan V. Mehrotra | Zendy; Harry A. Guess | Zendy; Emilio A. Emini | Zendy; John W. Shiver | Zendy

Open Access

Cross‐Reactivity of Anti–HIV‐1 T Cell Immune Responses among the Major HIV‐1 Clades in HIV‐1–Positive Individuals from 4 Continents

Author(s) -

Paul Coplan,

Swati Gupta,

Sheri Dubey,

Punnee Pitisuttithum,

Alex Nikas,

Bernard Mbewe,

Eftyhia Vardas,

Mauro Schechter,

Esper G. Kallás,

Dan Freed,

TongMing Fu,

T. Christopher Mast,

Pilaipan Puthavathana,

James G. Kublin,

Kelly Collins,

John Chisi,

Richard Pendame,

Scott J. Thaler,

Glenda Gray,

James McIntyre,

Walter L. Straus,

Jon H. Condra,

Devan V. Mehrotra,

Harry A. Guess,

Emilio A. Emini,

John W. Shiver

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/428450

Subject(s) - clade , biology , virology , immune system , cross reactivity , virus , immunology , genetics , gene , antibody , phylogenetics , cross reactions

The genetic diversity of human immunodeficiency virus type 1 (HIV-1) raises the question of whether vaccines that include a component to elicit antiviral T cell immunity based on a single viral genetic clade could provide cellular immune protection against divergent HIV-1 clades. Therefore, we quantified the cross-clade reactivity, among unvaccinated individuals, of anti-HIV-1 T cell responses to the infecting HIV-1 clade relative to other major circulating clades.

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