English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

unacceptably high rates of treatment failure [2, 3]. In vitro data indicate that the newer fluoroquinolones are active against Listeria species but have relatively poor penetration into the CNS, and ciprofloxacin used in a murine model of listeriosis was ineffective [4]. Linezolid is active against L. monocytogenes in vitro [5], and CSF concentrations of linezolid that are adequate for treatment have been attained in a rabbit model [6]. Additional data derived from the use of linezolid in neurosurgical settings, as well as the efficacy demonstrated in the treatment of CNS listeriosis in a murine model [7, 8], prompted us to use linezolid in the patient we describe. Rifampin crosses the blood-brain barrier, penetrates cell membranes, and is also active against L. monocytogenes. In a study of isolates recovered from patients with Listeria meningitis, rifampin and TMP-SMZ were the most potent monotherapeutic drugs tested [9]. Combination treatment involving rifampin and another active antimicrobial may reduce the emergence of resistance to rifampin. Our success with the combination of linezolid and rifampin may offer a valid alternative therapy for brain abscess caused by L. monocytogenes.

Nosocomial Outbreak of Hepatitis E Infection in Pakistan with Possible Parenteral Transmission