HIV‐1 Chemokine Coreceptor Utilization in Paired Cerebrospinal Fluid and Plasma Samples: A Survey of Subjects with Viremia | Zendy

Serena Spudich | Zendy; Wei Huang | Zendy; Annelie Nilsson | Zendy; Christos J. Petropoulos | Zendy; Teri Liegler | Zendy; Jeannette M. Whitcomb | Zendy; Richard W. Price | Zendy

Open Access

HIV‐1 Chemokine Coreceptor Utilization in Paired Cerebrospinal Fluid and Plasma Samples: A Survey of Subjects with Viremia

Author(s) -

Serena Spudich,

Wei Huang,

Annelie Nilsson,

Christos J. Petropoulos,

Teri Liegler,

Jeannette M. Whitcomb,

Richard W. Price

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/428095

Subject(s) - tropism , virology , tissue tropism , biology , cxcr4 , viremia , virus , cerebrospinal fluid , lentivirus , chemokine receptor , viral entry , phenotype , receptor , immunology , viral disease , chemokine , viral replication , gene , genetics , neuroscience

Chemokine receptors serve as coreceptors for human immunodeficiency virus type 1 (HIV-1) entry, influence cell tropism, and may critically determine central nervous system infection pathogenesis. Using an in vitro functional entry assay, we examined utilization of 2 principal coreceptors in cerebrospinal fluid (CSF) and plasma in 46 subjects.

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