TNF‐αPromoter Polymorphisms and Susceptibility to Human Papillomavirus 16–Associated Cervical Cancer | Zendy

Alina Deshpande | Zendy; John P. Nolan | Zendy; Paul S. White | Zendy; Yolanda E. Valdez | Zendy; William C. Hunt | Zendy; Cheri L. Peyton | Zendy; Cosette M. Wheeler | Zendy

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TNF‐αPromoter Polymorphisms and Susceptibility to Human Papillomavirus 16–Associated Cervical Cancer

Author(s) -

Alina Deshpande,

John P. Nolan,

Paul S. White,

Yolanda E. Valdez,

William C. Hunt,

Cheri L. Peyton,

Cosette M. Wheeler

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/427826

Subject(s) - cervical cancer , human papillomavirus , tumor necrosis factor alpha , virology , biology , promoter , genetics , papillomaviridae , cancer research , medicine , cancer , immunology , gene , gene expression

Polymorphisms in the TNF-alpha promoter region have recently been shown to be associated with susceptibility to cervical cancer. Some polymorphisms have been reported to influence transcription for this cytokine. Altered local levels in the cervix may influence an individual's immune response, thereby affecting persistence of human papillomavirus (HPV) 16 infection, a primary etiological factor for cervical cancer.

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