Different P105 Promoter Activities among Natural Variants of Human Papillomavirus Type 18 | Zendy

Laura Sichero | Zendy; Eduardo L. Franco | Zendy; Luisa L. Villa | Zendy

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Different P105 Promoter Activities among Natural Variants of Human Papillomavirus Type 18

Author(s) -

Laura Sichero,

Eduardo L. Franco,

Luisa L. Villa

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/427825

Subject(s) - promoter , promoter activity , hela , luciferase , human papillomavirus , biology , transfection , gene , virology , genetics , microbiology and biotechnology , cell culture , medicine , gene expression

Association between non-European variants of human papillomavirus (HPV) type 16 (HPV-16) and HPV-18 and cervical lesions has been suggested. To compare the P105 promoter activity among 6 HPV-18 variants, their complete long control regions (LCRs), as well as that of HeLa cells, were cloned upstream of the luciferase gene and transiently transfected in C33 cells. Whereas the B18-2 European variant showed the lowest promoter activity, the Asian-Amerindian variant, B18-3, had the highest activity. All variants tested were more active than the P97 HPV-16 prototype promoter. Differences in the LCR that impact P105 promoter activity could be responsible for the observed variability in oncogenic potential.

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