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Multiple Cytochrome b Mutations May Cause Atovaquone Resistance
Author(s) -
Steven R. Meshnick,
Bernard L. Trumpower
Publication year - 2005
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/427782
Subject(s) - atovaquone , cytochrome b , genetics , biology , mutation , virology , medicine , microbiology and biotechnology , gene , immunology , mitochondrial dna , malaria , plasmodium falciparum
Phillips and Lampe [1]. Given the rapid changes in HAART over the past decade— including marked improvements in potency, tolerability, and dosing frequency, it is doubtful that we will ever have an observational cohort in which patients receive the same therapy for 10 years. New therapies are certain to emerge that will be adopted, and the details of the research questions will change over time.

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