Human Leukocyte Antigen Class II Alleles and Rubella‐Specific Humoral and Cell‐Mediated Immunity following Measles‐Mumps‐Rubella–II Vaccination | Zendy

Inna G. Ovsyannikova | Zendy; Robert M. Jacobson | Zendy; Robert A. Vierkant | Zendy; Steven J. Jacobsen | Zendy; V. Shane Pankratz | Zendy; Gregory A. Poland | Zendy

Open Access

Human Leukocyte Antigen Class II Alleles and Rubella‐Specific Humoral and Cell‐Mediated Immunity following Measles‐Mumps‐Rubella–II Vaccination

Author(s) -

Inna G. Ovsyannikova,

Robert M. Jacobson,

Robert A. Vierkant,

Steven J. Jacobsen,

V. Shane Pankratz,

Gregory A. Poland

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/427558

Subject(s) - rubella , immunology , virology , mmr vaccine , vaccination , measles , measles mumps rubella vaccine , antigen , lymphoproliferative response , population , human leukocyte antigen , biology , rubella vaccine , medicine , genetics , peripheral blood mononuclear cell , environmental health , in vitro

We examined associations between human leukocyte antigen (HLA) class II genes and both rubella-specific immunoglobulin G antibodies and lymphoproliferative responses after measles-mumps-rubella-II (MMR-II) vaccination, in a population-based sample of 346 schoolchildren. The DPB1*0301, DPB1*0401, DPB1*1301, and DPB1*1501 alleles were significantly associated with rubella vaccine-induced antibodies. Alleles suggestive of being positively associated with rubella-specific lymphoproliferative stimulation indices were DPB1*0301, DQB1*0501, DRB1*0101, and DRB1*1104. Conversely, the DPB1*0401, DPB1*1001, DPB1*1101, DQB1*0202, and DRB1*0701 alleles were negatively associated with rubella-specific lymphoproliferation. This study of HLA class II-restricted humoral and cellular immune responses to rubella provides significant insight into mechanisms of vaccine response and new vaccine development.

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