Application of Nucleic Acid Sequence-Based Amplification for Diagnosis of and Monitoring the Clinical Course of Invasive Aspergillosis in Patients with Hematologic Diseases | Zendy

JinHong Yoo | Zendy; Jae Hyoung Choi | Zendy; SuMi Choi | Zendy; DongGun Lee | Zendy; Wan Shik Shin | Zendy; Woo Sung Min | Zendy; C.-C. Kim | Zendy

Open Access

Application of Nucleic Acid Sequence-Based Amplification for Diagnosis of and Monitoring the Clinical Course of Invasive Aspergillosis in Patients with Hematologic Diseases

Author(s) -

JinHong Yoo,

Jae Hyoung Choi,

SuMi Choi,

DongGun Lee,

Wan Shik Shin,

Woo Sung Min,

C.-C. Kim

Publication year - 2005

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/427284

Subject(s) - nasba , medicine , aspergillosis , galactomannan , gastroenterology , hematopoietic stem cell transplantation , immunology , transplantation , surgery , biology , dna , genetics , nucleic acid sequence

We evaluated nucleic acid sequence-based amplification (NASBA) and a galactomannan enzyme immunosorbent assay (GM-EIA) for the diagnosis of invasive aspergillosis (IA) in neutropenic febrile patients and for monitoring of its clinical course and outcome. Blood samples were collected twice per week from 128 patients with hematologic diseases during periods of neutropenic fever after undergoing chemotherapy or hematopoietic stem cell transplantation. A total of 448 blood samples were tested.

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