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A high intake of omega-3 polyunsaturated fatty acids (n-3 PUFAs) in mice causes impaired host resistance to Listeria monocytogenes. We wished to determine the role of interferon (IFN)-gamma signaling in this increased disease susceptibility.

Omega‐3 Polyunsaturated Fatty Acids Impair In Vivo Interferon‐γ Responsiveness via Diminished Receptor Signaling