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In animal models, treatment with 5H3, a fully human protective antigen-directed monoclonal antibody (PA-MAb), improved survival when administered close to the time of Bacillus anthracis lethal toxin (LeTx) bolus or live bacterial challenge. However, treatment with PA-MAb would be most valuable clinically if it were beneficial even when administered after the onset of shock and lethality due to LeTx.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Late Treatment with a Protective Antigen–Directed Monoclonal Antibody Improves Hemodynamic Function and Survival in a Lethal Toxin–Infused Rat Model of Anthrax Sepsis