Differential Interferon- Production Characterizes the Cytokine Responses to Leishmania and Mycobacterium leprae Antigens in Concomitant Mucocutaneous Leishmaniasis and Lepromatous Leprosy
Author(s) -
Diego Souza Matias Matos,
Rilza Beatriz Gayoso de Azeredo-Coutinho,
A Schubach,
Fátima ConceiçãoSilva,
C. Baptista,
João Soares Moreira,
Sergio C.F. Mendonça
Publication year - 2004
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/427069
Subject(s) - mycobacterium leprae , immunology , antigen , cutaneous leishmaniasis , immune system , lepromatous leprosy , leishmania , medicine , leishmaniasis , leishmania braziliensis , cellular immunity , leprosy , peripheral blood mononuclear cell , biology , in vitro , parasite hosting , biochemistry , world wide web , computer science
Tegumentary leishmaniasis and leprosy display similar spectra of disease phenotypes, which are dependent on cell-mediated immunity to specific antigens. Diffuse cutaneous leishmaniasis and lepromatous leprosy represent the anergic end of the spectrum, whereas mucocutaneous leishmaniasis and tuberculoid leprosy are associated with marked antigen-specific cellular immune response.
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