Quantitative T Cell Assay Reflects Infectious Load of Mycobacterium tuberculosis in an Endemic Case Contact Model | Zendy

Philip C. Hill | Zendy; Annette Fox | Zendy; David Jeffries | Zendy; Dolly Jackson-Sillah | Zendy; Moses D. Lugos | Zendy; Patrick K. Owiafe | Zendy; Simon Donkor | Zendy; Abdulrahman S. Hammond | Zendy; Tumani Corrah | Zendy; Richard A. Adegbola | Zendy; Keith P. W. J. McAdam | Zendy; Roger H. Brookes | Zendy

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Quantitative T Cell Assay Reflects Infectious Load of Mycobacterium tuberculosis in an Endemic Case Contact Model

Author(s) -

Philip C. Hill,

Annette Fox,

David Jeffries,

Dolly Jackson-Sillah,

Moses D. Lugos,

Patrick K. Owiafe,

Simon Donkor,

Abdulrahman S. Hammond,

Tumani Corrah,

Richard A. Adegbola,

Keith P. W. J. McAdam,

Roger H. Brookes

Publication year - 2004

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/427030

Subject(s) - elispot , medicine , immunology , tuberculosis , mycobacterium tuberculosis , antigen , tuberculin , esat 6 , immune system , virology , t cell , pathology

Currently, reliable efficacy markers for assessment of new interventions against tuberculosis (TB) are limited to disease and death. More precise measurement of the human immune response to Mycobacterium tuberculosis infection may be important. A qualitative enzyme-linked immunospot assay (ELISPOT) result for early secretory antigenic target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10) offers improved specificity over the purified protein derivative (PPD) skin test reaction in the detection of M. tuberculosis infection. We evaluated the quantitative ELISPOT and PPD skin test responses to recent M. tuberculosis exposure.

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