Fatal Severe Acute Respiratory Syndrome Is Associated with Multiorgan Involvement by Coronavirus | Zendy

Gabriella A. Farcas | Zendy; Susan M. Poutanen | Zendy; Tony Mazzulli | Zendy; Barbara Willey | Zendy; Jagdish Butany | Zendy; L. Sylvia | Zendy; Peter Faure | Zendy; Poolak Akhavan | Zendy; Donald E. Low | Zendy; Kevin C. Kain | Zendy

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Fatal Severe Acute Respiratory Syndrome Is Associated with Multiorgan Involvement by Coronavirus

Author(s) -

Gabriella A. Farcas,

Susan M. Poutanen,

Tony Mazzulli,

Barbara Willey,

Jagdish Butany,

L. Sylvia,

Peter Faure,

Poolak Akhavan,

Donald E. Low,

Kevin C. Kain

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/426870

Subject(s) - multiorgan failure , medicine , covid-19 , respiratory system , coronavirus , intensive care medicine , virology , outbreak , disease , infectious disease (medical specialty)

Severe acute respiratory syndrome (SARS) is characterized by pulmonary compromise; however, patients often have evidence of other organ dysfunction that may reflect extrapulmonary dissemination of SARS coronavirus (SARS-CoV). We report on the distribution and viral load of SARS-CoV in multiple organ samples from patients who died of SARS during the Toronto outbreak. SARS-CoV was detected in lung (100%), bowel (73%), liver (41%), and kidney (38%) in 19 patients who died of SARS, with the highest viral loads observed in lung (1.0 x 10(10) copies/g) and bowel (2.7 x 10(9) copies/g). Fatal SARS was associated with multiorgan viral dissemination in a distribution that has implications for disease manifestation, viral shedding, and transmission.

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