Dual Infections of the Central Nervous System with Epstein‐Barr Virus | Zendy

Adriana Weinberg | Zendy; Karen C. Bloch | Zendy; Shaobing Li | Zendy; YiWei Tang | Zendy; Megan Palmer | Zendy; Kenneth L. Tyler | Zendy

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Dual Infections of the Central Nervous System with Epstein‐Barr Virus

Author(s) -

Adriana Weinberg,

Karen C. Bloch,

Shaobing Li,

YiWei Tang,

Megan Palmer,

Kenneth L. Tyler

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/426402

Subject(s) - coinfection , virology , virus , biology , herpes simplex virus , varicella zoster virus , cytomegalovirus , mycoplasma pneumoniae , epstein–barr virus , herpesviridae , immunology , viral disease , medicine , pneumonia

We describe clinical and laboratory characteristics of 16 patients with central nervous system (CNS) infection caused by Epstein-Barr virus (EBV) and another pathogen. Seven of 10 immunocompromised patients had coinfection with viruses (3 with cytomegalovirus, 2 with JC virus, and 2 with varicella zoster virus) and 3 with nonviral pathogens (2 with pneumococcus and 1 with Cryptococcus species). Three of 6 immunocompetent patients had coinfections with viruses (1 each with herpes simplex virus, varicella zoster virus, and West Nile virus), and 3 had coinfections with nonviral pathogens (2 with Ehrlichia chaffeensis and 1 with Mycoplasma pneumoniae). The EBV load was similar in immunocompromised and immunocompetent patients and in patients with viral and nonviral coinfections. EBV lytic-cycle mRNA was detected in the cerebrospinal fluid of 5 of 6 tested samples, indicating EBV replication in the CNS during coinfection.

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