Brain‐Derived Neurotrophic Factor Protects against Multiple Forms of Brain Injury in Bacterial Meningitis | Zendy

YoengDelphine Bifrare | Zendy; Jürg Kummer | Zendy; Philipp Joss | Zendy; Martin G. Täuber | Zendy; Stephen L. Leib | Zendy

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Brain‐Derived Neurotrophic Factor Protects against Multiple Forms of Brain Injury in Bacterial Meningitis

Author(s) -

YoengDelphine Bifrare,

Jürg Kummer,

Philipp Joss,

Martin G. Täuber,

Stephen L. Leib

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/426399

Subject(s) - neurotrophic factors , meningitis , neuroprotection , medicine , brain derived neurotrophic factor , excitotoxicity , streptococcus pneumoniae , immunology , glutamate receptor , anesthesia , biology , surgery , microbiology and biotechnology , receptor , antibiotics

Brain-derived neurotrophic factor (BDNF) blocks activation of caspase-3, reduces translocation of apoptosis-inducing factor (AIF), attenuates excitotoxicity of glutamate, and increases antioxidant enzyme activities. The mechanisms of neuroprotection suggest that BDNF may be beneficial in bacterial meningitis.

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