Ex Vivo Characterization of Early Secretory Antigenic Target 6-Specific T Cells at Sites of Active Disease in Pleural Tuberculosis | Zendy

Katalin A. Wilkinson | Zendy; Robert J. Wilkinson | Zendy; Ansar A. Pathan | Zendy; Katie Ewer | Zendy; Mithilesh Prakash | Zendy; Paul Klenerman | Zendy; Nick Maskell | Zendy; R. Wayne Davies | Zendy; Geoffrey Pasvol | Zendy; Ajit Lalvani | Zendy

Open Access

Ex Vivo Characterization of Early Secretory Antigenic Target 6-Specific T Cells at Sites of Active Disease in Pleural Tuberculosis

Author(s) -

Katalin A. Wilkinson,

Robert J. Wilkinson,

Ansar A. Pathan,

Katie Ewer,

Mithilesh Prakash,

Paul Klenerman,

Nick Maskell,

R. Wayne Davies,

Geoffrey Pasvol,

Ajit Lalvani

Publication year - 2004

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/426139

Subject(s) - medicine , tuberculosis , immunology , antigen , in vivo , ex vivo , effector , pathology , biology , microbiology and biotechnology

Presence of early secretory antigenic target-6 (ESAT-6)-specific, interferon- gamma -secreting T cells in blood accurately marks tuberculosis infection. In tuberculous pleural effusions from 10 patients with tuberculosis, these cells were concentrated a mean of 15-fold (standard deviation, +/-6-fold), relative to their level in peripheral blood (P=.014), and displayed rapid effector function. Such cells were absent in 8 control patients with nontuberculous pleural disease. The recruitment of ESAT-6-specific T cells to inflamed tuberculous tissue demonstrates their function in vivo and suggests a novel way to diagnose tuberculous pleuritis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research