Immune Reconstitution Inflammatory Syndrome Associated with Kaposi Sarcoma during Potent Antiretroviral Therapy | Zendy

Elizabeth Connick | Zendy; Michael A. C. Kane | Zendy; I. White | Zendy; John Ryder | Zendy; Timothy Campbell | Zendy

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Immune Reconstitution Inflammatory Syndrome Associated with Kaposi Sarcoma during Potent Antiretroviral Therapy

Author(s) -

Elizabeth Connick,

Michael A. C. Kane,

I. White,

John Ryder,

Timothy Campbell

Publication year - 2004

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/426078

Subject(s) - medicine , immune reconstitution inflammatory syndrome , sarcoma , immune system , immunology , chemotherapy , immunopathology , lymphocyte , viral load , clearance , inflammation , antiretroviral therapy , paclitaxel , kaposi's sarcoma , pathology , human immunodeficiency virus (hiv) , human herpesvirus , urology

Rapidly progressive Kaposi sarcoma (KS) lesions with lymphadenopathy and tissue swelling occurred in a patient during antiretroviral treatment, despite an increased CD4(+) lymphocyte count and decreased HIV-1 level and KS-associated herpesvirus replication, suggesting immune reconstitution inflammatory syndrome. Inflammation resolved coincident with decreases in the CD4(+) lymphocyte count during paclitaxel treatment, whereas KS cleared only after prolonged antiretroviral therapy and chemotherapy.

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