Mycobacterial Dissemination and Cellular Responses after 1‐Lobe Restricted Tuberculosis Infection of Genetically Susceptible and Resistant Mice | Zendy

Vladimir V. Mischenko | Zendy; Marina A. Kapina | Zendy; Evgenyi B. Eruslanov | Zendy; Elena Kondratieva | Zendy; Irina V. Lyadova | Zendy; Douglas B. Young | Zendy; Alexander Apt | Zendy

Open Access

Mycobacterial Dissemination and Cellular Responses after 1‐Lobe Restricted Tuberculosis Infection of Genetically Susceptible and Resistant Mice

Author(s) -

Vladimir V. Mischenko,

Marina A. Kapina,

Evgenyi B. Eruslanov,

Elena Kondratieva,

Irina V. Lyadova,

Douglas B. Young,

Alexander Apt

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/425909

Subject(s) - mycobacterium tuberculosis , tuberculosis , immune system , biology , immunology , cd8 , lung , interferon gamma , mycobacterium , congenic , microbiology and biotechnology , pathology , medicine , gene , biochemistry

To study mycobacterial dissemination and immune-cell trafficking in tuberculosis, we developed a mouse model in which we introduced 1 microL of Mycobacterium tuberculosis directly into the middle lobe of the right lung. We investigated the kinetics of both mycobacterial spread to different anatomical sites and recruitment of phagocytes and activated lymphocytes.

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