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An enhanced presence of 9-O-acetylated sialoglycoconjugates (9-O-AcSGs) triggers the alternate pathway (AP) in Indian visceral leishmaniasis (VL). Antibodies directed against these epitopes are present in high titers. The biological relevance of these antibodies, with regard to activation of the classical pathway (CP), was investigated.

Antibodies Directed againstO‐Acetylated Sialoglycoconjugates Accelerate Complement Activation inLeishmania donovaniPromastigotes