Antibodies Directed againstO‐Acetylated Sialoglycoconjugates Accelerate Complement Activation inLeishmania donovaniPromastigotes | Zendy

Sumi Mukhopadhyay | Zendy; Mitali Chatterjee | Zendy; Tanusree Das | Zendy; Suman Bandyopadhyay | Zendy; Shyam Sundar | Zendy; Chitra Mandal | Zendy

Open Access

Antibodies Directed againstO‐Acetylated Sialoglycoconjugates Accelerate Complement Activation inLeishmania donovaniPromastigotes

Author(s) -

Sumi Mukhopadhyay,

Mitali Chatterjee,

Tanusree Das,

Suman Bandyopadhyay,

Shyam Sundar,

Chitra Mandal

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/425519

Subject(s) - complement system , propidium iodide , leishmania donovani , alternative complement pathway , biology , antibody , epitope , classical complement pathway , leishmania , microbiology and biotechnology , complement membrane attack complex , flow cytometry , biochemistry , immunology , parasite hosting , visceral leishmaniasis , programmed cell death , apoptosis , leishmaniasis , world wide web , computer science

An enhanced presence of 9-O-acetylated sialoglycoconjugates (9-O-AcSGs) triggers the alternate pathway (AP) in Indian visceral leishmaniasis (VL). Antibodies directed against these epitopes are present in high titers. The biological relevance of these antibodies, with regard to activation of the classical pathway (CP), was investigated.

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