Open AccessVariable Resistance to Palivizumab in Cotton Rats by Respiratory Syncytial Virus Mutants
Author(s) -
Xiaodong Zhao,
FuPing Chen,
A. George Megaw,
Wayne M. Sullender
Publication year - 2004
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/425515
Subject(s) - palivizumab , mutant , virus , virology , neutralization , biology , mutation , in vitro , in vivo , respiratory system , gene , biochemistry , genetics , anatomy
Palivizumab (PZ) is the only monoclonal antibody in use against a human infectious disease. PZ is given as prophylaxis against infection with respiratory syncytial virus (RSV). An RSV escape mutant, MP4, has been shown to resist PZ prophylaxis in cotton rats.
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