Influence of Host Genetic Variation on Susceptibility to HIV Type 1 Infection | Zendy

Richard A. Kaslow | Zendy; Tevfik Dorak | Zendy; James Tang | Zendy

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Influence of Host Genetic Variation on Susceptibility to HIV Type 1 Infection

Author(s) -

Richard A. Kaslow,

Tevfik Dorak,

James Tang

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/425269

Subject(s) - host (biology) , virus , biology , genetic variation , virology , transmission (telecommunications) , immunology , viral replication , genetic variability , human immunodeficiency virus (hiv) , host factors , genetics , genotype , gene , electrical engineering , engineering

For this review of genetic susceptibility to human immunodeficiency virus type 1 infection, far more information was available on factors involved in acquisition of the virus by an uninfected "recipient" than on propagation by the infected "donor." Genetic variation presumably alters transmission from an infected host primarily by regulating the replication of virus and the concentration of particles circulating in blood and mucosal secretions of the potential donor. Thus, the effects of host genetic variation on transmission are inextricably bound to the well-established and powerful effects on virus load at different stages of infection. Teasing apart the effects in both donors and recipients has been and will continue to be quite difficult.

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