Two Patients with Cryptococcal Meningitis and Idiopathic CD4 Lymphopenia: Defective Cytokine Production and Reversal by Recombinant Interferon- Therapy | Zendy

M. G. Netea | Zendy; Annemarie E. Brouwer | Zendy; E Hoogendoorn | Zendy; J.W.M. van der Meer | Zendy; M. I. Koolen | Zendy; Paul E. Verweij | Zendy; Bart Jan Kullberg | Zendy

Open Access

Two Patients with Cryptococcal Meningitis and Idiopathic CD4 Lymphopenia: Defective Cytokine Production and Reversal by Recombinant Interferon- Therapy

Author(s) -

M. G. Netea,

Annemarie E. Brouwer,

E Hoogendoorn,

J.W.M. van der Meer,

M. I. Koolen,

Paul E. Verweij,

Bart Jan Kullberg

Publication year - 2004

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/425121

Subject(s) - immunology , medicine , cytokine , proinflammatory cytokine , interferon gamma , immunotherapy , tumor necrosis factor alpha , cryptococcus neoformans , immune system , inflammation , biology , microbiology and biotechnology

Although Cryptococcus neoformans is a fungal pathogen that causes human disease predominantly in the immunocompromised host, severe cryptococcal infections are occasionally encountered in apparently immunocompetent individuals. Activation of cellular immunity by proinflammatory cytokines plays a central role in anticryptococcal defense.

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