Early Plasmacytoid Dendritic Cell Changes Predict Plasma HIV Load Rebound during Primary Infection | Zendy

Jérôme Pacanowski | Zendy; Leyla Develioglu | Zendy; Isabelle Kamga | Zendy; Martine Sinet | Zendy; Moı̈se Desvarieux | Zendy; PierreMarie Girard | Zendy; Anne Hosmalin | Zendy

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Early Plasmacytoid Dendritic Cell Changes Predict Plasma HIV Load Rebound during Primary Infection

Author(s) -

Jérôme Pacanowski,

Leyla Develioglu,

Isabelle Kamga,

Martine Sinet,

Moı̈se Desvarieux,

PierreMarie Girard,

Anne Hosmalin

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/425020

Subject(s) - immunology , viral load , virus , human immunodeficiency virus (hiv) , flow cytometry , dendritic cell , immune system , plasmacytoid dendritic cell , medicine , antiretroviral therapy , virology , lentivirus , viral disease , biology

During human immunodeficiency virus (HIV) infection, interruption of highly active antiretroviral therapy (HAART) is usually followed by virus load rebound. Previous data have suggested a role for plasmacytoid dendritic cells (pDCs) in anti-HIV innate immunity. Here, the number of pDCs was measured by flow cytometry before, during, and after receipt of HAART in 7 patients with documented primary HIV-1 infection. A negative correlation was evidenced between pDC counts after 1 month of HAART and mean plasma virus load after interruption of HAART (r2=0.85; Spearman's partial rho =-0.92; P=.03). pDC counts during treatment might help predict immune replication control after interruption of HAART.

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