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In a comparison of rates of acquired immunodeficiency syndrome (AIDS)-defining malignancies (ADMs) for 1989-1996 versus 1997-2002, we found a decrease in ADMs (rate ratio, 0.31; P&lt;.0001) and a significant increase in non-AIDS-defining malignancies (non-ADMs; rate ratio, 10.87; P&lt;.0002). The mean CD4 cell count was lower among patients with ADMs than among those with non-ADMs. A longer duration of survival during highly active antiretroviral therapy might explain the increasing incidence of non-ADMs.

Trends in AIDS-Defining and Non--AIDS-Defining Malignancies among HIV-Infected Patients: 1989-2002