Paradoxical Inflammatory Reaction during Treatment of Cryptococcus neoformans var. gattii Meningitis in an HIV-Seronegative Woman | Zendy

Lloyd Einsiedel | Zendy; David Gordon | Zendy; John R. Dyer | Zendy

Open Access

Paradoxical Inflammatory Reaction during Treatment of Cryptococcus neoformans var. gattii Meningitis in an HIV-Seronegative Woman

Author(s) -

Lloyd Einsiedel,

David Gordon,

John R. Dyer

Publication year - 2004

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/424746

Subject(s) - cryptococcus neoformans , medicine , cryptococcosis , meningitis , immunology , cerebrospinal fluid , cryptococcus , antifungal , inflammation , microbiology and biotechnology , surgery , biology , dermatology

A human immunodeficiency virus (HIV)-seronegative woman was admitted to the hospital with postpartum onset Cryptococcus neoformans var. gattii meningitis and markedly increased intracranial pressure. A poor initial response to antifungal therapy was followed, 2 months after hospital admission, by severe acute meningeal and cerebral inflammation and clearance of yeast cells from cerebrospinal fluid. This first reported case of paradoxical inflammatory reaction to C. neoformans illustrates important aspects of the host-pathogen interaction and highlights possible effects of immunomodulatory therapies.

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