Control of Epstein‐Barr Virus Load and Lymphoproliferative Disease by Maintenance of CD8+T Lymphocytes in the T Lymphocyte–Depleted Graft after Bone Marrow Transplantation | Zendy

Julián TorreCisneros | Zendy; Javier GómezRomán | Zendy; Antonio Torres | Zendy; Concha Herrera | Zendy; Juan José Castón | Zendy; Antonio Rivero | Zendy; María Eva MingotCastellano | Zendy; Rafael Rojas | Zendy; Carmen Martín | Zendy; Francisco Martínez | Zendy; Pedro Gómez | Zendy

Open Access

Control of Epstein‐Barr Virus Load and Lymphoproliferative Disease by Maintenance of CD8⁺T Lymphocytes in the T Lymphocyte–Depleted Graft after Bone Marrow Transplantation

Author(s) -

Julián TorreCisneros,

Javier GómezRomán,

Antonio Torres,

Concha Herrera,

Juan José Castón,

Antonio Rivero,

María Eva MingotCastellano,

Rafael Rojas,

Carmen Martín,

Francisco Martínez,

Pedro Gómez

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/424602

Subject(s) - cd8 , lymphoproliferative disorders , epstein–barr virus , immunology , medicine , lymphocyte , bone marrow , viral load , virus , t lymphocyte , lymphoproliferative response , lymphoproliferative disease , virology , immune system , biology , lymphoma , peripheral blood mononuclear cell , biochemistry , in vitro

Of 100 bone marrow transplant recipients, 30 (30%) received a CD4(+) lymphocyte-depleted graft (1x10(6) CD8(+) T lymphocytes/kg of body weight). Replication of Epstein-Barr virus (EBV) was observed in 40 patients (40%). The use of a CD4(+) lymphocyte-depleted graft was the only independent risk factor for replication of EBV (relative risk, 11.5; 95% confidence interval, 5.8-22.8; P<.0001). Nevertheless, EBV load in those patients was not higher than in the rest of patients, and the low EBV load prevented the development of lymphoproliferative disease. These results suggest that the presence of CD8(+) T lymphocytes in the bone marrow graft can control EBV load, thereby reducing the risk of developing lymphoproliferative disease.

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