Colostrum Obtained from Women Vaccinated with Pneumococcal Vaccine during Pregnancy Inhibits Epithelial Adhesion ofStreptococcus pneumoniae | Zendy

Hedwig E. Deubzer | Zendy; Stephen Obaro | Zendy; Vanessa O. Newman | Zendy; Richard A. Adegbola | Zendy; Brian Greenwood | Zendy; Don Henderson | Zendy

Open Access

Colostrum Obtained from Women Vaccinated with Pneumococcal Vaccine during Pregnancy Inhibits Epithelial Adhesion ofStreptococcus pneumoniae

Author(s) -

Hedwig E. Deubzer,

Stephen Obaro,

Vanessa O. Newman,

Richard A. Adegbola,

Brian Greenwood,

Don Henderson

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/424597

Subject(s) - colostrum , streptococcus pneumoniae , serotype , vaccination , immunology , pneumococcal infections , breast milk , medicine , pneumococcal vaccine , pregnancy , antibody , breast feeding , microbiology and biotechnology , streptococcaceae , biology , pediatrics , biochemistry , genetics , antibiotics

Prevention of nasopharyngeal colonization may reduce the burden of pneumococcal infection during infancy. Colostrum obtained from Gambian mothers who had been vaccinated with either Pneumovax II or Mengivax A&C (n=8 per group) during pregnancy was examined for inhibition of adherence of Streptococcus pneumoniae serotypes 6B and 14 to pharyngeal epithelial cells in vitro. Pneumococcal adherence was significantly reduced in the presence of breast milk (P< or =.0001 for S. pneumoniae serotype 14; P=.036 for serotype 6B), independent of the concentration of secretory IgA antibodies. Maternal vaccination with polyvalent pneumococcal polysaccharide vaccine boosts the capacity of colostrum to inhibit adherence of pneumococci to pharyngeal epithelial cells. In breast-feeding populations, maternal vaccination might prevent pneumococcal disease in young infants.

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