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Valacyclovir exhibits better oral absorption and higher, more prolonged serum concentrations than oral acyclovir. The efficacy of valacyclovir and acyclovir on genital herpes simplex virus (HSV) shedding was assessed in a double-blind, 3-period crossover trial.

Valacyclovir and Acyclovir for Suppression of Shedding of Herpes Simplex Virus in the Genital Tract