Screening for Mutations Related to Atovaquone/Proguanil Resistance in Treatment Failures and Other Imported Isolates ofPlasmodium falciparumin Europe | Zendy

Ole Wichmann | Zendy; Nikolai Muehlberger | Zendy; Tomáš Jelı́nek | Zendy; Michael Alifrangis | Zendy; Gabriele PeyerlHoffmann | Zendy; Marion Mühlen | Zendy; Martin P. Grobusch | Zendy; Joaquím Gascón | Zendy; Alberto Matteelli | Zendy; Hermann Laferl | Zendy; Zeno Bisoffi | Zendy; Stephan Ehrhardt | Zendy; Juan CuadrosGonzález | Zendy; Christoph Hatz | Zendy; Ida Gjørup | Zendy; Paul McWhinney | Zendy; Jiřı́ Beran | Zendy; Saraiva da Cunha | Zendy; Marco H. Schulze | Zendy; Herwig Kollaritsch | Zendy; Peter Kern | Zendy; Graham Fry | Zendy; Joachim Richter | Zendy

Open Access

Screening for Mutations Related to Atovaquone/Proguanil Resistance in Treatment Failures and Other Imported Isolates ofPlasmodium falciparumin Europe

Author(s) -

Ole Wichmann,

Nikolai Muehlberger,

Tomáš Jelı́nek,

Michael Alifrangis,

Gabriele PeyerlHoffmann,

Marion Mühlen,

Martin P. Grobusch,

Joaquím Gascón,

Alberto Matteelli,

Hermann Laferl,

Zeno Bisoffi,

Stephan Ehrhardt,

Juan CuadrosGonzález,

Christoph Hatz,

Ida Gjørup,

Paul McWhinney,

Jiřı́ Beran,

Saraiva da Cunha,

Marco H. Schulze,

Herwig Kollaritsch,

Peter Kern,

Graham Fry,

Joachim Richter

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/424469

Subject(s) - atovaquone , proguanil , plasmodium falciparum , medicine , point mutation , virology , biology , genetics , malaria , mutation , gene , immunology

Two single-point mutations of the Plasmodium falciparum cytochrome b gene (Tyr268Asn and Tyr268Ser) were recently reported in cases of atovaquone/proguanil (Malarone) treatment failure. However, little is known about the prevalence of codon-268 mutations and their quantitative association with treatment failure.

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