Efficacy of Monthly Tafenoquine for Prophylaxis ofPlasmodium vivaxand Multidrug‐ResistantP. falciparumMalaria | Zendy

Douglas S. Walsh | Zendy; Chirapa Eamsila | Zendy; Theerayuth Sasiprapha | Zendy; Suebpong Sangkharomya | Zendy; Pradith Khaewsathien | Zendy; Panpaka Supakalin | Zendy; Douglas B. Tang | Zendy; Phongsak Jarasrumgsichol | Zendy; Chainarong Cherdchu | Zendy; Michael D. Edstein | Zendy; Karl H. Rieckmann | Zendy; Thomas G. Brewer | Zendy

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Efficacy of Monthly Tafenoquine for Prophylaxis ofPlasmodium vivaxand Multidrug‐ResistantP. falciparumMalaria

Author(s) -

Douglas S. Walsh,

Chirapa Eamsila,

Theerayuth Sasiprapha,

Suebpong Sangkharomya,

Pradith Khaewsathien,

Panpaka Supakalin,

Douglas B. Tang,

Phongsak Jarasrumgsichol,

Chainarong Cherdchu,

Michael D. Edstein,

Karl H. Rieckmann,

Thomas G. Brewer

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/424468

Subject(s) - malaria , plasmodium vivax , plasmodium falciparum , placebo , medicine , primaquine , immunology , chloroquine , pathology , alternative medicine

We assessed monthly doses of tafenoquine for preventing Plasmodium vivax and multidrug-resistant P. falciparum malaria. In a randomized, double-blind, placebo-controlled study, 205 Thai soldiers received either a loading dose of tafenoquine 400 mg (base) daily for 3 days, followed by single monthly 400-mg doses (n = 104), or placebo (n = 101), for up to 5 consecutive months. In volunteers completing follow-up (96 tafenoquine and 91 placebo recipients), there were 22 P. vivax, 8 P. falciparum, and 1 mixed infection. All infections except 1 P. vivax occurred in placebo recipients, giving tafenoquine a protective efficacy of 97% for all malaria (95% confidence interval [CI], 82%-99%), 96% for P. vivax malaria (95% CI, 76%-99%), and 100% for P. falciparum malaria (95% CI, 60%-100%). Monthly tafenoquine was safe, well tolerated, and highly effective in preventing P. vivax and multidrug-resistant P. falciparum malaria in Thai soldiers during 6 months of prophylaxis.

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