Induction of Human T Cell–Mediated Immune Responses after Primary and Secondary Smallpox Vaccination
Author(s) -
Jeffrey S. Kennedy,
Sharon E. Frey,
Lihan Yan,
Alan L. Rothman,
John Cruz,
Frances K. Newman,
Laura Orphin,
Robert B. Belshe,
Francis A. Ennis
Publication year - 2004
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/423848
Subject(s) - vaccinia , immune system , vaccination , smallpox , smallpox vaccine , immunology , virology , immunity , medicine , poxviridae , smallpox vaccination , biology , biochemistry , gene , recombinant dna
Postexposure vaccination strategies rely on a rapid induction of poxvirus-specific immune responses. Postvaccination cell-mediated immune (CMI) responses have not been compared by use of controlled trials in previously vaccinated (vaccinia-nonnaive) and nonvaccinated (vaccinia-naive) individuals.
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