Genotypic Resistance in HIV‐1–Infected Patients with Persistently Detectable Low‐Level Viremia while Receiving Highly Active Antiretroviral Therapy | Zendy

Richard E. Nettles | Zendy; Tara L. Kieffer | Zendy; Rachel P. Simmons | Zendy; Joseph Cofrancesco | Zendy; Richard D. Moore | Zendy; Joel E. Gallant | Zendy; Deborah Persaud | Zendy; Robert F. Siliciano | Zendy

Open Access

Genotypic Resistance in HIV‐1–Infected Patients with Persistently Detectable Low‐Level Viremia while Receiving Highly Active Antiretroviral Therapy

Author(s) -

Richard E. Nettles,

Tara L. Kieffer,

Rachel P. Simmons,

Joseph Cofrancesco,

Richard D. Moore,

Joel E. Gallant,

Deborah Persaud,

Robert F. Siliciano

Publication year - 2004

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/423388

Subject(s) - viremia , genotyping , medicine , resistance mutation , virology , drug resistance , viral load , genotype , lentivirus , virus , viral disease , immunology , polymerase chain reaction , biology , reverse transcriptase , genetics , gene

Technical limitations in the sensitivity of commercial genotyping methods may prevent clinicians from determining whether drug-resistant human immunodeficiency virus type 1 (HIV-1) is present in patients with low-level viremia. We performed ultrasensitive HIV-1 genotyping for patients with persistent plasma virus loads of 50-400 copies/mL to better define the prevalence of drug resistance and the most common resistance mutations during persistently detectable low-level viremia.

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