Analysis of Genetic Polymorphisms in CCR5, CCR2, Stromal Cell–Derived Factor–1, RANTES, and Dendritic Cell–Specific Intercellular Adhesion Molecule–3–Grabbing Nonintegrin in Seronegative Individuals Repeatedly Exposed to HIV‐1 | Zendy

Huanliang Liu | Zendy; Yon Hwangbo | Zendy; Sarah Holte | Zendy; Jean Lee | Zendy; Chunhui Wang | Zendy; Nicole Kaupp | Zendy; Haiying Zhu | Zendy; Connie Celum | Zendy; Lawrence Corey | Zendy; M. Juliana McElrath | Zendy; Tuofu Zhu | Zendy

Open Access

Analysis of Genetic Polymorphisms in CCR5, CCR2, Stromal Cell–Derived Factor–1, RANTES, and Dendritic Cell–Specific Intercellular Adhesion Molecule–3–Grabbing Nonintegrin in Seronegative Individuals Repeatedly Exposed to HIV‐1

Author(s) -

Huanliang Liu,

Yon Hwangbo,

Sarah Holte,

Jean Lee,

Chunhui Wang,

Nicole Kaupp,

Haiying Zhu,

Connie Celum,

Lawrence Corey,

M. Juliana McElrath,

Tuofu Zhu

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/423209

Subject(s) - biology , immunology , chemokine , chemokine receptor , stromal cell derived factor 1 , virology , stromal cell , intercellular adhesion molecule 1 , intercellular adhesion molecule , dendritic cell , cell adhesion molecule , cell adhesion , cell , cxcr4 , genetics , inflammation , immune system , cancer research

To determine the influence of host genetics on human immunodeficiency virus (HIV) type 1 infection, we examined 94 repeatedly exposed seronegative (ES) individuals for polymorphisms in multiple genes and compared the results with those for 316 HIV-1-seropositive and 425 HIV-1-seronegative individuals. The frequency of homozygous C-C chemokine receptor (CCR) 5- Delta 32 was higher in ES (3.2%) than in HIV-1-seropositive individuals (0.0%; P=.012). However, the CCR5-59029A, CCR2-64I, stromal cell-derived factor (SDF)-1-3'A, RANTES (regulated on activation, normally T cell-expressed and -secreted)-403A, and RANTES-28G polymorphisms were not associated with resistance to HIV-1 infection. Furthermore, we identified novel variants in the DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin) repeat region and observed that heterozygous DC-SIGN reduced the risk of HIV-1 infection (3.2% in ES individuals vs. 0.0% in HIV-1-seropositive individuals; P=.011).

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