Polymorphism of Fc Receptor IIa for Immunoglobulin G Is Associated with Placental Malaria in HIV‐1–Positive Women in Western Kenya | Zendy

Kimberly C. Brouwer | Zendy; Altaf A. Lal | Zendy; Lisa B. Mirel | Zendy; Juliana Otieno | Zendy; John Ayisi | Zendy; Anna Maria van Eijk | Zendy; Renu B. Lal | Zendy; Richard W. Steketee | Zendy; Bernard L. Nahlen | Zendy; Ya Ping Shi | Zendy

Open Access

Polymorphism of Fc Receptor IIa for Immunoglobulin G Is Associated with Placental Malaria in HIV‐1–Positive Women in Western Kenya

Author(s) -

Kimberly C. Brouwer,

Altaf A. Lal,

Lisa B. Mirel,

Juliana Otieno,

John Ayisi,

Anna Maria van Eijk,

Renu B. Lal,

Richard W. Steketee,

Bernard L. Nahlen,

Ya Ping Shi

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/422850

Subject(s) - malaria , subclass , genotype , antibody , immunology , biology , immunoglobulin g , virology , fc receptor , human immunodeficiency virus (hiv) , receptor , polymorphism (computer science) , genetics , gene

Genetic polymorphism of the Fc receptor IIa for immunoglobulin (Ig) G (Fc gamma RIIa) determines IgG subclass binding. Previous studies have shown that individuals with the IgG1/3-binding Fc gamma RIIa-Arg/Arg131 genotype are relatively protected against high-density malaria, whereas individuals with the IgG2-binding Fc gamma RIIa-His/His131 genotype are at increased risk for developing cerebral malaria. The present study was undertaken to examine the relationship between Fc gamma RIIa polymorphism and placental malaria (PM) in pregnant women of known human immunodeficiency virus (HIV)-1 status.

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