The Search for a Predictor of CD4 Cell Count Continues: Total Lymphocyte Count Is Not a Substitute for CD4 Cell Count in the Management of HIV-Infected Individuals in a Resource-Limited Setting | Zendy

N O Akinola | Zendy; Olayinka Olasode | Zendy; I A Adediran | Zendy; ‎Olaniyi Onayemi | Zendy; A. Murainah | Zendy; Omolola Irinoye | Zendy; A.A. Elujoba | Zendy; M. A. Durosinmi | Zendy

Open Access

The Search for a Predictor of CD4 Cell Count Continues: Total Lymphocyte Count Is Not a Substitute for CD4 Cell Count in the Management of HIV-Infected Individuals in a Resource-Limited Setting

Author(s) -

N O Akinola,

Olayinka Olasode,

I A Adediran,

‎Olaniyi Onayemi,

A. Murainah,

Omolola Irinoye,

A.A. Elujoba,

M. A. Durosinmi

Publication year - 2004

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/422722

Subject(s) - medicine , lymphocyte , immunology , human immunodeficiency virus (hiv) , cd4 t cell , cell , count data , lymphocyte subsets , t cell , immune system , biology , statistics , mathematics , poisson distribution , genetics

Total lymphocyte count (TLC) has been recommended as a substitute for CD4 cell count for the management of HIV-infected individuals living in resource-limited settings. To confirm this, 151 TLCs and CD4 cell counts were obtained from 109 patients who had not yet started treatment and analyzed. CD4 cell counts of <200 cells/mm3 were found in 42 cases (37.8%) with TLCs of > or =1200 cells/mm3. Thus, 1 in 3 individuals would have been deprived of needed treatment. Therefore, in this setting, TLC is not a reliable predictor of CD4 cell count in HIV-infected individuals.

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