Topical Cidofovir Is More Effective than Is Parenteral Therapy for Treatment of Progressive Vaccinia in Immunocompromised Mice | Zendy

Donald F. Smee | Zendy; Kevin W. Bailey | Zendy; MinHui Wong | Zendy; Miles K. Wandersee | Zendy; Robert W. Sidwell | Zendy

Open Access

Topical Cidofovir Is More Effective than Is Parenteral Therapy for Treatment of Progressive Vaccinia in Immunocompromised Mice

Author(s) -

Donald F. Smee,

Kevin W. Bailey,

MinHui Wong,

Miles K. Wandersee,

Robert W. Sidwell

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/422696

Subject(s) - cidofovir , medicine , vaccinia , poxviridae , virus , orthopoxvirus , vaccination , immunology , surgery , virology , biology , biochemistry , gene , recombinant dna

Severe complications may arise as a result of virus dissemination after smallpox (live vaccinia virus) vaccination, particularly in immunocompromised individuals. We developed a new mouse model for studying the effects of antiviral agents on progressive vaccinia virus infections.

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