Induction of Protective Immunity against Lethal Anthrax Challenge with a Patch | Zendy

Richard T. Kenney | Zendy; Jianmei Yu | Zendy; Mimi GuebreXabier | Zendy; Sarah A. Frech | Zendy; Adam Lambert | Zendy; Brigitte Heller | Zendy; Larry Ellingsworth | Zendy; James E. Eyles | Zendy; E. Diane Williamson | Zendy; Gregory M. Glenn | Zendy

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Induction of Protective Immunity against Lethal Anthrax Challenge with a Patch

Author(s) -

Richard T. Kenney,

Jianmei Yu,

Mimi GuebreXabier,

Sarah A. Frech,

Adam Lambert,

Brigitte Heller,

Larry Ellingsworth,

James E. Eyles,

E. Diane Williamson,

Gregory M. Glenn

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/422694

Subject(s) - bacillus anthracis , anthrax vaccines , anthrax toxin , vaccination , immunization , adjuvant , medicine , immunology , immunity , immune system , antigen , virology , microbiology and biotechnology , biology , dna vaccination , fusion protein , recombinant dna , biochemistry , genetics , bacteria , gene

Transcutaneous immunization (TCI) is a needle-free technique that delivers antigens and adjuvants to potent epidermal immune cells. To address critical unmet needs in biodefense against anthrax, we have designed a novel vaccine delivery system using a dry adhesive patch that simplifies administration and improves tolerability of a subunit anthrax vaccine.

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