HIV Type 1 and Cytomegalovirus Coinfection in the Female Genital Tract | Zendy

Nell S. Lurain | Zendy; Emmanuel S. Robert | Zendy; Jiahong Xu | Zendy; Margaret Camarca | Zendy; Alan Landay | Zendy; Andrea Kovács | Zendy; Patricia Reichelderfer | Zendy

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HIV Type 1 and Cytomegalovirus Coinfection in the Female Genital Tract

Author(s) -

Nell S. Lurain,

Emmanuel S. Robert,

Jiahong Xu,

Margaret Camarca,

Alan Landay,

Andrea Kovács,

Patricia Reichelderfer

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/422533

Subject(s) - coinfection , cytomegalovirus , betaherpesvirinae , human cytomegalovirus , virology , viral disease , immunology , saliva , biology , virus , immunopathology , sex organ , cytokine , herpesviridae , medicine , biochemistry , genetics

The relationship between human immunodeficiency virus (HIV) type 1 and human cytomegalovirus (CMV) was studied in blood, saliva, and cervicovaginal lavage (CVL) specimens from 33 HIV-1-infected women. An association between HIV-1 RNA and CMV DNA was found in the CVL specimens, which also were tested for cytokine levels. Women with detectable CMV DNA in CVL specimens were more likely to have higher interleukin (IL)-1 beta and IL-8 levels than were women with undetectable CMV DNA in CVL specimens. More than 1 strain of CMV was detected in specimens from 2 patients. These results suggest mechanisms by which CMV coinfection could affect HIV-1 disease progression.

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