Iron Regulates Hepatitis C Virus Translation via Stimulation of Expression of Translation Initiation Factor 3 | Zendy

Igor Theurl | Zendy; Heinz Zoller | Zendy; Peter Obrist | Zendy; Christian Datz | Zendy; Felix Bachmann | Zendy; Richard M. Elliott | Zendy; Günter Weiß | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Iron Regulates Hepatitis C Virus Translation via Stimulation of Expression of Translation Initiation Factor 3

Author(s) -

Igor Theurl,

Heinz Zoller,

Peter Obrist,

Christian Datz,

Felix Bachmann,

Richard M. Elliott,

Günter Weiß

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/422261

Subject(s) - hepatitis c virus , translation (biology) , biology , messenger rna , eukaryotic translation , gene expression , hepacivirus , virology , virus , microbiology and biotechnology , gene , biochemistry

Although the response to treatment with interferon- alpha in individuals with chronic hepatitis C virus (HCV) infection is negatively associated with increased liver iron stores, the underlying mechanisms at work have remained elusive to date. The translation initiation factor 3 (eIF3) is essential for HCV translation, and thus the effects that iron perturbations have on eIF3 expression and HCV translation were studied here.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research