Design of Aerosolized Amphotericin B Formulations for Prophylaxis Trials among Lung Transplant Recipients | Zendy

John R. Perfect | Zendy; Elizabeth Dodds Ashley | Zendy; Richard H. Drew | Zendy

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Design of Aerosolized Amphotericin B Formulations for Prophylaxis Trials among Lung Transplant Recipients

Author(s) -

John R. Perfect,

Elizabeth Dodds Ashley,

Richard H. Drew

Publication year - 2004

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/421958

Subject(s) - amphotericin b , medicine , amphotericin b deoxycholate , aerosolization , lung , intensive care medicine , drug , pharmacokinetics , lung transplantation , antifungal , pharmacology , antifungal drug , clinical trial , inhalation , anesthesia , dermatology , caspofungin

Emphasis has been placed on the need for antifungal prophylaxis when transplanted organs are directly exposed to the environment. In lung transplantation, one strategy for prevention has been aerosolization of polyenes into the lung. Despite widespread use of amphotericin B aerosols, there are still few studies on how to validate their effectiveness or optimize pharmacokinetics.

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