Variation in the Shiga Toxin Region of 20th‐Century Epidemic and EndemicShigella dysenteriae1 Strains | Zendy

Karla M. Greco | Zendy; Marie A. McDonough | Zendy; Joan R. Butterton | Zendy

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Variation in the Shiga Toxin Region of 20th‐Century Epidemic and EndemicShigella dysenteriae1 Strains

Author(s) -

Karla M. Greco,

Marie A. McDonough,

Joan R. Butterton

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/421706

Subject(s) - shigella dysenteriae , shiga toxin , prophage , biology , shigella , microbiology and biotechnology , virology , clone (java method) , polymerase chain reaction , escherichia coli , genetics , bacteriophage , gene

The Shiga toxin (Stx) region of Shigella dysenteriae 1 lies on a defective prophage homologous to lambdoid bacteriophages in Stx-producing Escherichia coli. S. dysenteriae 1 strains obtained in locations throughout the world over the course of the past 60 years were assessed for variations in the Stx region by use of polymerase chain reaction and sequence analysis. The defective prophage was present in all strains examined, suggesting that all S. dysenteriae 1 isolates derive from a clone that resulted from a single phage-integration event. All western-hemisphere strains have an additional iso-IS1 insertion element upstream of stxAB, implying that there has been minimal exchange of strains between hemispheres in recent decades.

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