Open AccessIncomplete Correlation of Serum Vibriocidal Antibody Titer with Protection fromVibrio choleraeInfection in Urban Bangladesh
Author(s) -
Debasish Saha,
Regina C. LaRocque,
Ashraful Islam Khan,
Jason B. Harris,
Yasmin Ara Begum,
Syed M. Akramuzzaman,
Abu S. G. Faruque,
Edward T. Ryan,
Firdausi Qadri,
Stephen B. Calderwood
Publication year - 2004
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/421275
Subject(s) - vibrio cholerae , cholera , titer , cholera vaccine , antibody , antibody titer , virology , microbiology and biotechnology , medicine , vibrionaceae , immunology , biology , bacteria , genetics
The serum vibriocidal antibody is the only recognized predictor of protection from cholera, but no seroepidemiological data have been gathered since the emergence of Vibrio cholerae O139. We assessed the association between the vibriocidal antibody titer and protection from cholera in an endemic setting. Although a higher baseline vibriocidal titer correlated with protection from V. cholerae O1, infection still developed in some contacts with very high titers. No association between baseline vibriocidal titer and protection from V. cholerae O139 infection was found. Our findings suggest that the vibriocidal antibody is an incomplete predictor of protection from V. cholerae infection.
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