Rotavirus Immunoglobulin A Responses Stimulated by Each of 3 Doses of a Quadrivalent Human/Bovine Reassortant Rotavirus Vaccine | Zendy

Richard L. Ward | Zendy; David I. Bernstein | Zendy; Vicki E. Smith | Zendy; D. S. Sander | Zendy; Alan Shaw | Zendy; Joseph Eiden | Zendy; Penny M. Heaton | Zendy; Paul A. Offit | Zendy; H. F. Clark | Zendy

Open Access

Rotavirus Immunoglobulin A Responses Stimulated by Each of 3 Doses of a Quadrivalent Human/Bovine Reassortant Rotavirus Vaccine

Author(s) -

Richard L. Ward,

David I. Bernstein,

Vicki E. Smith,

D. S. Sander,

Alan Shaw,

Joseph Eiden,

Penny M. Heaton,

Paul A. Offit,

H. F. Clark

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/421248

Subject(s) - virology , rotavirus , reoviridae , antibody , rotavirus vaccine , immunoglobulin g , rotavirus infections , medicine , biology , immunology , virus

A quadrivalent precursor to the pentavalent rotavirus vaccine candidate RotaTeq was evaluated in a 3-dose, 439-subject study. To determine immunogenicity, the quantity of rotavirus immunoglobulin A (IgA) in stool specimens obtained, at 1 of 10 study sites, from 37 placebo and 37 vaccine recipients was measured. None of the placebo recipients showed a clinically important (>/=3-fold) increase in stool rotavirus IgA, whereas 31 vaccine recipients showed an increase after at least 1 dose of vaccine. In total, 16, 19, and 15 vaccine recipients had increases after 1, 2, and 3 doses, respectively, indicating that a 3-dose regimen increased the immune response elicited by this vaccine.

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