Inhibition of the Tissue Factor/Factor VIIa Pathway Does Not Influence the Inflammatory or Antibacterial Response to Abdominal Sepsis Induced byEscherichia coliin Mice | Zendy

Sebastian Weijer | Zendy; Saskia H. H. F. Schoenmakers | Zendy; Sandrine Florquin | Zendy; Marcel Levi | Zendy; George P. Vlasuk | Zendy; William E. Rote | Zendy; Pieter H. Reitsma | Zendy; C. Arnold Spek | Zendy; Tom van der Poll | Zendy

Open Access

Inhibition of the Tissue Factor/Factor VIIa Pathway Does Not Influence the Inflammatory or Antibacterial Response to Abdominal Sepsis Induced byEscherichia coliin Mice

Author(s) -

Sebastian Weijer,

Saskia H. H. F. Schoenmakers,

Sandrine Florquin,

Marcel Levi,

George P. Vlasuk,

William E. Rote,

Pieter H. Reitsma,

C. Arnold Spek,

Tom van der Poll

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/421031

Subject(s) - tissue factor , sepsis , peritonitis , immunology , coagulation , fibrin , peritoneal cavity , escherichia coli , tissue factor pathway inhibitor , chemokine , thromboplastin , microbiology and biotechnology , pharmacology , biology , medicine , inflammation , biochemistry , anatomy , gene

Anticoagulants have gained increasing attention for the treatment of sepsis. Inhibition of the tissue factor (TF)/factor (F) VIIa pathway has been shown to attenuate the activation of coagulation and to prevent death in a primate model of sepsis caused by gram-negative bacteria.

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