Open AccessAssociation between Common Toll‐Like Receptor 4 Mutations and Severe Respiratory Syncytial Virus Disease
Author(s) -
Guy Tal,
Avigdor Mandelberg,
Ilan Dalal,
Karine Cesar,
Eli Somekh,
Asher Tal,
Anat Oron,
Svetlana Itskovich,
Ami Ballin,
Sion Houri,
Avraham Beigelman,
Ofer Lider,
Gideon Rechavi,
Ninette Amariglio
Publication year - 2004
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/420830
Subject(s) - bronchiolitis , immunology , cd14 , genotype , virus , biology , toll like receptor , medicine , virology , immune system , innate immune system , gene , genetics
The clinical spectrum of respiratory syncytial virus (RSV) bronchiolitis in previously healthy infants is extremely variable. Thus, it is likely that factors such as genetic heterogeneity contribute to disease severity. Toll-like receptor 4 (TLR4) and CD14 are part of a receptor complex involved in the innate immune response to RSV.