Adverse Reactions to Accidental Forearm Injection of Bacille Calmette-Guerin Vaccine in Schoolchildren: 12-Month Cohort Follow-up | Zendy

Seth A. Gross | Zendy; Ernesto Kahan | Zendy; L. Vesterman | Zendy; Ofra Havkin | Zendy; Alex Leventhal | Zendy

Open Access

Adverse Reactions to Accidental Forearm Injection of Bacille Calmette-Guerin Vaccine in Schoolchildren: 12-Month Cohort Follow-up

Author(s) -

Seth A. Gross,

Ernesto Kahan,

L. Vesterman,

Ofra Havkin,

Alex Leventhal

Publication year - 2004

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/392505

Subject(s) - medicine , vaccination , accidental , bcg vaccine , cohort , forearm , adverse effect , intradermal injection , tuberculin , surgery , dermatology , immunology , pathology , tuberculosis , physics , acoustics

This study examined the natural history of reaction after accidental intradermal administration of bacille Calmette-Guerin (BCG) vaccine instead of purified protein derivative (PPD) in 226 schoolchildren. At 18 days after vaccination, a local reaction with a diameter of 4.5-14 mm was found in 62% of the students, and ulceration with discharge was found in 26.6%; corresponding rates at 120 days were 72.3% and 38% and at 281 days were 73% and 6%. At 345 days, 85% of the students had a dry scar measuring 5-14 mm in diameter, and none had ulceration or discharge.

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