Minor Mutations in HIV Protease at Baseline and Appearance of Primary Mutation 90M in Patients for Whom Their First Protease‐Inhibitor Antiretroviral Regimens Failed | Zendy

Carlo Federico Perno | Zendy; Alessandro CozziLepri | Zendy; Federica Forbici | Zendy; Ada Bertoli | Zendy; Michela Violin | Zendy; María Stella Mura | Zendy; G. P. Cadeo | Zendy; Anna Orani | Zendy; Antonio Chirianni | Zendy; Carlo de Stefano | Zendy; Claudia Balotta | Zendy; Antonella d’Arminio Monforte | Zendy

Open Access

Minor Mutations in HIV Protease at Baseline and Appearance of Primary Mutation 90M in Patients for Whom Their First Protease‐Inhibitor Antiretroviral Regimens Failed

Author(s) -

Carlo Federico Perno,

Alessandro CozziLepri,

Federica Forbici,

Ada Bertoli,

Michela Violin,

María Stella Mura,

G. P. Cadeo,

Anna Orani,

Antonio Chirianni,

Carlo de Stefano,

Claudia Balotta,

Antonella d’Arminio Monforte

Publication year - 2004

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/386307

Subject(s) - protease , odds ratio , virology , protease inhibitor (pharmacology) , mutation , biology , confidence interval , clade , logistic regression , virus , immunology , medicine , viral load , genetics , gene , antiretroviral therapy , phylogenetics , biochemistry , enzyme

The association between minor mutations in human immunodeficiency virus (HIV) protease at baseline and development of common primary mutation 90M at virological failure (conferring some resistance to all protease inhibitors [PIs]) was evaluated in 93 previously drug-naive patients experiencing failure of their first PI-based antiretroviral regimens. In logistic regression analysis, the probability of accumulating a new 90M mutation at virological failure was associated with the presence at baseline of minor mutation 36I (naturally occurring in approximately 25% of HIV clade B and in >80% of HIV non-clade-B viruses) (adjusted odds ratio, 13.5 [95% confidence interval, 1.89-95.6]; P=.009) and, possibly, of 10I/V. This suggests a potential role for the presence of 36I at baseline in predicting the appearance of 90M at virological failure.

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